Platelet-rich plasma (PRP) is a substance that has been gaining importance in treating orthopaedic and sports injuries. PRP, in addition to having high concentrations of platelets, has been found to have high concentrations of growth factors. Both of these promote tissue healing and regeneration. As a result, PRP has found applications in musculoskeletal injuries, most commonly in chronic tendinopathy and muscle injury. This article reviews the biological properties, physiological actions, methods of preparation, and uses of PRP.